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Commonly used estimates of the genetic contribution to disease are subject to the same fallacies as bad luck estimates

Published 12 November 2019 The scientific debate following the initial formulation of the “bad luck” hypothesis in cancer development highlighted how measures based on analysis of variance are inappropriately used for risk communication. The notion of “explained” variance is not only used to quantify randomness, but also to quantify genetic and environmental contribution to disease in heritability

https://www.lupop.lu.se/article/commonly-used-estimates-genetic-contribution-disease-are-subject-same-fallacies-bad-luck-estimates - 2025-01-08

Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study

Published 13 November 2019 Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative breast cancers (TNBCs) for which associated treatment and outcome data were collected between 2010 and 2015 via the population-based Sweden Cancerome Analysis Network–Breast (SCAN-B) project (ClinicalTrials.go

https://www.lupop.lu.se/article/whole-genome-sequencing-triple-negative-breast-cancers-population-based-clinical-study - 2025-01-08

Population-Based Observational Studies in Oncology: Proceed With Caution

Published 14 November 2019 A principle goal of research in Oncology is to determine the optimal treatment for our patients. This often takes the form of comparing 2 existing therapies to one another to determine which is superior, or to introduce a new therapy and determine if it is superior or noninferior to the existing standard of care. New publication in Seminars in Radiation Oncology

https://www.lupop.lu.se/article/population-based-observational-studies-oncology-proceed-caution - 2025-01-08

Validation of diagnosis codes to identify side of colon in an electronic health record registry

Published 15 November 2019 ICD codes are a highly reliable indicator of tumor location when the specific location code is entered in the EHR. However, non-specific side of colon ICD codes are present for a sizable minority of patients, and structured data alone may not be adequate to support testing of some research hypotheses. New publication in BMC Medical Research Methodology

https://www.lupop.lu.se/article/validation-diagnosis-codes-identify-side-colon-electronic-health-record-registry - 2025-01-08

Quasi-experimental designs for impact evaluation in epidemiology and public health: theory and practice

By anna [dot] axmon [at] med [dot] lu [dot] se (Anna Axmon) - published 12 December 2018 PhD course in applied epidemiology Impact evaluation is an attempt to assess whether changes in outcomes can be convincingly attributed to interventions and is a key to informed decision-making and ultimately better population health. When randomized controlled trials (RCTs) are not feasible, quasi-experiments

https://www.lupop.lu.se/article/quasi-experimental-designs-impact-evaluation-epidemiology-and-public-health-theory-and-practice - 2025-01-08